Standardized definitions of molecular response in chronic myeloid leukemia
نویسندگان
چکیده
منابع مشابه
Monitoring molecular response in chronic myeloid leukemia.
Before the advent of tyrosine kinase inhibitor (TKI) therapy, the evaluation of hematologic and cytogenetic responses was sufficient to gauge treatment efficacy in patients with chronic myeloid leukemia. However, with more potent TKI therapies, the majority of patients achieve complete cytogenetic response. Furthermore, deeper molecular responses are now commonly achieved, necessitating a relia...
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PURPOSE To discuss the importance of regular, consistent use of molecular testing to monitor treatment response and minimal residual disease in patients with chronic myeloid leukemia (CML), as recommended in established practice guidelines. DESIGN This review outlines the efficacy of BCR-ABL1 tyrosine kinase inhibitors (TKIs) in eliciting significant treatment responses in patients with CML; ...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2012
ISSN: 0887-6924,1476-5551
DOI: 10.1038/leu.2012.104